Intravascular imaging – Lipid rich plaque burden
Subclinical atherosclerosis
Interplay of traditional and novel cardiovascular risk factors
Projects
Lipid rich plaque burden – Predictors, modifies, and prognostic implications
Near-infrared spectroscopy (NIRS) intravascular ultrasound imaging can detect lipid-rich plaques. Lipid-rich plaques are associated with major acute cardiovascular events. We aim to evaluate the effect of established and innovative risk factors such as systemic and local inflammation, lipidomics, and innovative theapeutic approaches of on Lipid-rich plaques and their dynamic changes over time.
Cardiovascular risk factors interplay
Atherosclerosis is the underlying cause of coronary heart disease (CHD) worldwide. Atherosclerosis typically begins to develop early in life and progresses slowly over decades before the development of symptoms or clinical events. Traditional causal cardiovascular risk factors including hypertension, smoking, or hypercholesterolemia, are well known, but they each carry limited predictive value for future clinical events. We aim to study the interplay of traditional as well as novel cardiovascular risk factors in patients with subclinical atherosclerosis and patients with established coronary artery disease.
Cooperation
Cleveland Clinic, Robert & Suzanne Tomsich Department of Cardiovascular Medicine, Cleveland, OH, USA
Victorian Heart Hospital, Monash University, Australia
ISAS Dortmund, Dortmund, Germany
Funding
- UMEA2 – Advanced Clinical Scientist, founded by Federal Ministry of Education and Research (BMBF) 2023 to Dr. Iryna Dykun
- Internal research funding for clinicians (IFORES) 2022 to Dr. Iryna Dykun
- German Research Foundation (DFG) 2021-2022 to Dr. Iryna Dykun
- German Cardiac Society (DGK) research grant 2013 to Dr. Iryna Dykun
Awards
Abstract Award from the German Cardiac Society (DGK) in the section „Research in clinical Lipidology “, 2025
Abstract Award from the German Cardiac Society (DGK) in the section „Research in clinical Lipidology “, 2024
Abstract Award from the German Cardiac Society (DGK) in the section „Research in clinical Lipidology “, 2022
Abstract Award nomination from the German Cardiac Society (DGK), 2014
Five relevant publications
Dykun I, Kampf J, Rassaf T, Mahabadi AA (2023). Interaction between elevated lipoprotein(a) and LDL cholesterol on mortality risk in patients with coronary artery disease. Eur J Prev Cardiol. Sep 20;30(13):e64-e65.
Dykun I, Clark C, Carlo J, Lincoff AM, Menon V, Nissen SE, Nicholls SJ, Puri R (2022). Longitudinal High-Sensitivity C-reactive Protein and Longer-term Cardiovascular Outcomes in Optimally-treated Patients with High-Risk Vascular Disease. Am J Cardiol. Aug 12
Dykun I, Mincu R, Hendricks S, Balcer B, Totzeck M, Rassaf T, Mahabadi AA (2020). Efficacy of lipid-lowering therapy beyond statins to prevent cardiovascular events: a meta-analysis. Eur J Prev Cardiol.15:1675-1678.
Dykun I, Mahababi AA, Rassaf T (2020). A clinical perspective on the 2019 ESC/EAS guidelines for management of dyslipidaemias: PCSK-9 ihnibirors for all? Eur Heart J. 21;41(24):2331
Dykun I, Lehmann N, Kälsch H, Möhlenkamp S, Moebus S, Budde T, Seibel R, Grönemeyer D, Jöckel KH, Erbel R, Mahabadi AA (2016). Statin Medication Enhances Progression of Coronary Artery Calcification: The Heinz Nixdorf Recall Study. J Am Coll Cardiol. 8;68(19):2123-2125.
Pubmed
