|Office:||MFZ 3. OG Room 03.026|
|Telefon:||+49 201 723 6011|
|Fax:||+49 201 723 6973|
PD Dr. rer. nat. Ulrike Hendgen-Cotta received her Diploma in 2004 from the Ruhr University Bochum (RUB) in Biology with the specialization in Parasitology and Neurobiochemistry. She performed her diploma thesis with focus on the insect vector of Chagas Disease. In 2008 she earned her Dr. rer. nat. at the University Essen-Duisburg, Faculty of Biology, under the mentorship of Prof. Rassaf with the thesis „Myoglobin-mediated reduction of nitrite to nitric oxide: Impact on the myocardial ischemia/reperfusion injury. Since 2009 she joined the RWTH Aachen, Department of Cardiology, Pneumology and Angiology and the University Hospital Düsseldorf, Department for Cardiology, Pneumology and Angiology, as the Experimental Leader of the Heisenberg-Group of Prof. Rassaf and as Director of the Cardiology Lab since 2010. In August 2015, she moved to the University Hospital Essen where she is currently Head of the CardioScienceLabs at the Department of Cardiology. In 2017 Dr. rer. nat. Hendgen-Cotta obtained habilitation and venia legendi in Experimental Cardiology („Impact of Nitrite and Nitrate on Pathological and Aged-related Alterations of the Cardiovascular System“).
Our lab aims to integrate physiological, pharmacological, biochemical and molecular biological techniques to study basic and translational aspects relating to the pathophysiology and treatment of cardiovascular diseases. Particular interest is on ischemia/reperfusion injury and cardiac repair, heart failure, physiological adaptations under hypoxia, lipotoxicity and aging with main focus on regulation of mitochondrial energetics and integrity, innate immune response, calcium cycle, nitric oxide metabolism, associated signal transduction mechanisms and posttranslational protein modification as tractable therapeutic targets.
- Pohl J, Hendgen-Cotta UB, Rammos C, Luedike P, Mull E, Stoppe C, Jülicher K, Luedike H, Merx MW, Kelm M, Bernhagen J, Rassaf T 2015 – Targeted intracellular accumulation of macrophage migration inhibitory factor in the reperfused heart mediates cardioprotection. Thromb Haemost. 114(6).
- Rammos C, Totzeck M, Deenen R, Köhrer K, Kelm M, Rassaf T, Hendgen-Cotta UB 2015 – Dietary nitrate is a modifier of vascular gene expression in old male mice. Oxid Med Cell Longev. 2015:658264.
- Totzeck M, Schicho A, Stock P, Kelm M, Rassaf T, Hendgen-Cotta UB 2015 – Nitrite circumvents canonical cGMP signaling to enhance proliferation of myocyte precursor cells. Mol Cell Biochem. 401:175-83.
- Totzeck M, Hendgen-Cotta UB, Kelm M, Rassaf T 2014 Crosstalk between nitrite, myoglobin and reactive oxygen species to regulate vasodilation under hypoxia. PLoS One. 9:e105951.
- Rassaf T, Totzeck M, Hendgen-Cotta UB, Shiva S, Heusch G, Kelm M 2014 – Circulating nitrite contributes to cardioprotection by remote ischemic preconditioning. Circ Res. 114:1601-10.
- Rammos C, Hendgen-Cotta UB, Sobierajski J, Bernard A, Kelm M, Rassaf T – 2014 Dietary nitrate reverses vascular dysfunction in older adults with moderately increased cardiovascular risk. J Am Coll Cardiol. 63:1584-5.
- Hendgen-Cotta UB, Luedike P, Totzeck M, Kropp M, Schicho A, Stock P, Rammos C, Niessen M, Heiss C, Lundberg JO, Weitzberg E, Kelm M, Rassaf T 2012 – Dietary nitrate supplementation improves revascularization in chronic ischemia. Circulation. 126:1983-92.
- Totzeck M, Hendgen-Cotta UB, Luedike P, Berenbrink M, Klare JP, Steinhoff HJ, Semmler D, Shiva S, Williams D, Kipar A, Gladwin MT, Schrader J, Kelm M, Cossins AR, Rassaf T 2012 – Nitrite regulates hypoxic vasodilation via myoglobin-dependent nitric oxide generation. Circulation. 126:325-34.
- Luedike P, Hendgen-Cotta UB, Sobierajski J, Totzeck M, Reeh M, Dewor M, Lue H, Krisp C, Wolters D, Kelm M, Bernhagen J, Rassaf T 2012 – Cardioprotection through S-nitros(yl)ation of macrophage migration inhibitory factor. Circulation. 125:1880-9.
- Hendgen-Cotta UB, Merx MW, Shiva S, Schmitz J, Becher S, Klare JP, Steinhoff HJ, Goedecke A, Schrader J, Gladwin MT, Kelm M, Rassaf T 2008 – Nitrite reductase activity of myoglobin regulates respiration and cellular viability in myocardial ischemia-reperfusion injury. Proc Natl Acad Sci USA. 105:10256-61.
- Rassaf T, Flögel U, Drexhage C, Hendgen-Cotta U, Kelm M, Schrader J 2007 – Nitrite reductase function of deoxymyoglobin: oxygen sensor and regulator of cardiac energetics and function. Circ Res. 100:1749-54.