skip to Main Content

So finden Sie uns!

Das Westdeutsche Herz- und Gefäßzentrum Essen mit der Klinik für Kardiologie und Angiologie befindet sich auf dem Gelände des Universitätsklinikums Essen. Sollten Sie die Routenplanung selbst vornehmen wollen, dann schauen Sie unsere Wegbeschreibung oder benutzen Sie bitte folgende Postadresse:

Hufelandstr. 55 | 45122 Essen

Bleiben sie mit uns in Kontakt

Fax: +49 (201) 723 - 5480
Lageplan des Klinikums

Standort

Aging

Age-related changes of the cardiovascular system lay the basis for an increased cardiovascular disease risk. Ventricular-vascular stiffness and impaired relaxation are resulting, lead to clinical vascular and cardiac diseases and are causal for increased morbidity in the elderly. We focus on unraveling the mechanistic, molecular and cellular basis of the age-related changes of the cardiovascular system.

Research Groups:
PD Dr. med. Christos Rammos

I/R Injury - Mitochondrial Dysfunction

Ischemia/Reperfusion injury results from the first minutes of reperfusion. A key pathologic event in cardiac ischemia/reperfusion injury is mitochondrial perturbation rendering the cardiomyocytes to necrotic or apoptotic cell death. We focus on the signaling pathways, which converge the death signals on mitochondria determining the cardiomyocytes fate.

Research Group:
PD Dr. rer. nat. Ulrike Hendgen-Cotta

Cardiac Repair

Massive loss of cardiomyocytes in acute cardiac events overwhelms the limited regenerative capacity of the myocardium. We are studying the key signaling pathways of regulation of the inflammatory response in cardiac repair.

Research Group:
PD Dr. med. Matthias Totzeck

Inflammation / Heart failure

Diseases, such as atherosclerosis or myocardial infarction, feature well orchestrated inflammatory responses. Innate and adaptive immune cells are critically involved in the acute and chronic damage of heart and vasculature, but also carry out remodeling.
We are studying the control and contribution of monocyte/macrophage and lymphocyte subsets in cardiovascular disease.

Research Groups:
Dr. med. Peter Lüdike
Dr. med. Martin Steinmetz

Onco-Cardiology

Cancer therapies can have deleterious effects on the cardiovascular system. These include myocardial dysfunction, arrhythmias, myocardial ischemia, pulmonary hypertension, thrombo-embolic events, accelerated atherosclerosis, pericardial and valvular heart diseases. We are studying the underlying mechanisms of the toxicity.

Research Groups:
PD Dr. med. Matthias Totzeck
PD Dr. rer. nat. Ulrike Hendgen-Cotta

Lipotoxicity

Continuous contractile activity of the heart is essential and the required energy is mostly provided by fatty acid oxidation. Myocardial lipid accumulation can lead to pathological responses. We focus on the role of cardiac myoglobin in governing fatty acid metabolism to ensure the physiological energy production through β-oxidation and preventing myocardial lipid accumulation.

Research Groups:
PD Dr. med. Matthias Totzeck
PD Dr. rer. nat. Ulrike Hendgen-Cotta

Back To Top