The research group deals with the investigation of cell death-activating mechanisms and the lipid metabolism in the scope of cardiac diseases. The main goal is to identify new molecular targets within the pro-death signaling pathways and to validate inhibitors for therapeutic application.
The current projects focus on heart damage in reperfusion after myocardial ischemia, after ischemic stroke, and by cancer immunotherapeutic agents. A further focus is the analysis of the dynamic lipid metabolism. In particular, we address mitochondrial morphology, energetics, dysfunction, communication and cell death regulation.
The research group is concerned with the underlying pathomechanisms within the scope of acute cardiac events. Myocardial ischaemia and rebuilding are caused by acute myocardial infarction (the so-called ischemia / reperfusion injury) as well as the myocardial ischemia caused by tumor therapy (oncological cardiology, chemotherapy, radiotherapy, immunotherapy). The main goal is the development of new therapies to improve the mortality and morbidity of the affected patients. For this purpose, new signaling pathways (CD47, thrombospondins, interaction of nitric monoxide hemoproteins) are investigated experimentally and within the scope of clinical trials.
The research group focuses on unraveling the mechanistic, molecular and cellular basis of age-related changes of the cardiovascular system with special emphasis on novel strategies and treatment techniques. We are using translational approaches to gain a holistic understanding of age-related cardiovascular functions and to reveal novel treatment modalities counteracting age-related diseases. We ultimately aim at translating these novel strategies to treat human cardiovascular disease.
The research group is concerned with the influence and regulation of inflammatory cytokines on myocardial infarction, immune reaction and regeneration after myocardial ischemia / reperfusion. The main focus lies on the role of pro-inflammatory cytokine Macrophage migration inhibitory factor (MIF), it’s ubiquity and importance in cardiovascular medicine resp. cardiac insufficiency, which is largely unknown until today. In addition to the analysis of post-translational protein modifications such as S-nitrosion in various animal models, i.e. myocardial infarction or Hind limb ischaemia model, our interest is in particular the linkage of molecular biology Basic research with clinical questions in acute and intensive care medicine.