skip to Main Content

So finden Sie uns!

Das Westdeutsche Herz- und Gefäßzentrum Essen mit der Klinik für Kardiologie und Angiologie befindet sich auf dem Gelände des Universitätsklinikums Essen. Sollten Sie die Routenplanung selbst vornehmen wollen, dann schauen Sie unsere Wegbeschreibung oder benutzen Sie bitte folgende Postadresse:

Hufelandstr. 55 | 45122 Essen

Bleiben sie mit uns in Kontakt

Fax: +49 (201) 723 - 5480
Lageplan des Klinikums

Standort

Basic science projects

The current projects focus on heart damage in reperfusion after myocardial ischemia, after ischemic stroke, and by cancer immunotherapeutic agents. A further focus is the analysis of the dynamic lipid metabolism. In particular, we address mitochondrial morphology, energetics, dysfunction, communication and cell death regulation.

Funding
Else Kröner-Fresenius-Stiftung

Hans und Gertie Fischer-Stiftung

Collaborations
  • Dr. rer. nat. Robert Ahrens, Arbeitsgruppe Lipidomics, Leibniz-Institut für Analytische Wissenschaften – ISAS e.V., Dortmund
  • Prof. Dr. rer nat. Jürgen Bernhagen, Institut für Schlaganfall und Demenzforschung, Klinikum der Universität München
  • Prof. Dr. rer. nat. Michael Ehrmann, Fakultät für Biologie, Zentrum für Medizinische Biotechnologie, Universität Duisburg-Essen
  • Prof. Dr. rer. nat. Ulrich Flögel, Institut für Molekulare Kardiologie, Universitätsklinikum Düsseldorf
  • Prof. Dr. rer. nat. Jojo Haendeler, Leibniz-Institut für Umwelt-Medizinische Forschung ( IUF), Düsseldorf
  • PD Dr. rer. nat. Iris Helfrich, Klinik für Dermatologie, AG Vaskuläre Onkologie & Metastasierung Universitätsklinikum Essen
  • Dr. rer. nat. Johann Klare, Fakultät für Physik, Universität Osnabrück
  • Dr. rer. nat. Stine Mencl, Klinik für Neurologie, AG Thromboinflammation, Universitätsklinikum Essen
  • Prof. Dr. rer. nat. Raphael Stoll, Fakultät für Chemie und Biochemie, Ruhr-Universität Bochum
  • Prof. Dr. rer. nat. Elke Winterhager, Electron Microscopy Unit, Imaging Center Essen, Universitätsklinikum Essen
  • Prof. Brent A. French, Department of Biomedical Engineering, University of Virginia, USA
  • Prof. Gerhard Gröbner, Department of Chemistry, Umea University, Schweden
  • Dr. Ilkka Miinalainen, Biocenter Oulu, University of Oulu, Finnland
Myocardial ischemia/reperfusion injury

Ischemia/Reperfusion injury results from the first minutes of reperfusion. A key pathologic event in cardiac ischemia/reperfusion injury is mitochondrial perturbation rendering the cardiomyocytes to necrotic or apoptotic cell death. We focus on the signaling pathways, which converge the death signals on mitochondria determining the cardiomyocytes fate.

Cardiac lipid metabolism

Continuous contractile activity of the heart is essential and the required energy is mostly provided by fatty acid oxidation. Myocardial lipid accumulation can lead to pathological responses. We focus on the role of cardiac myoglobin in governing fatty acid metabolism to ensure the physiological energy production through β-oxidation and preventing myocardial lipid accumulation spectroscopy.

Cardiac injury and dysfunction following ischemic stroke

In cerebral ischemic events, the occurrence of acute myocardial injury is common and associated with increased morbidity and mortality. Stroke in the right hemispheric insular cortex induces activation of the sympathetic nervous system resulting in high circulating cardiac troponin levels reflecting myocardial damage. Whether mitochondrial dysfunction plays a crucial role in stroke induced neurogenic cardiac damage is unknown. We hypothesize that sympathetic input to the heart by excessive norepinephrine release induces damage of cardiac mitochondria, which is a major cause for myocardial injury. We will characterize catecholamine toxicity and identify intracellular molecular pathways of mitochondrial damage that act as a central switch for myocardial damage post-stroke.

Characterization of immune checkpoint inhibitor influence on the heart in preclinical model

Immune checkpoint inhibitors play an increasing role in modern anti-tumor therapy.
The immune system has numerous mechanisms to prevent excessive immune response. After T cells activation, certain inhibitory signal molecules, so-called „checkpoints“, are up-regulated on T cells. Via these “checkpoints” tumor cells are able to override the immune defense which is usually directed against them. Checkpoint inhibitors are capable of inhibiting the inhibitory signaling pathways, reactivate T cells and thus give the immune system the opportunity to attack the tumor. However, activation of the body’s immune response against tumor cells can induce cardiotoxic reactions leading to myocarditis, cardiomyopathy and myocardial fibrosis, as well as acute heart failure.
The aim of the present project is the characterization of immunotherapy-induced changes in the murine heart and identification of possible mechanisms that may lead to cardiac damage.

Main Publications
  • Hendgen-Cotta UB, Esfeld S, Coman C, Ahrends R, Klein-Hitpass L, Flögel U, Rassaf T, Totzeck M. A novel phsiological role of cardiac myoglobin in lipid metabolism. Sci Rep. 2017; 7:43219
  • Hendgen-Cotta UB, Messiha D, Esfeld S, Deenen R, Rassaf T, Totzeck M. Inorganic nitrite modulates miRNA signatures in acute myocardial in vivo ischemia/reperfusion. Free Radic Res. 2017; 51: 91-102
  • Esfeld S, Jastrow H, Rassaf T, Winterhager E, Hendgen-Cotta UB. Distinct separation of cardiac subsarcolemmal and interfibrillar mitochondria: Mission impossible? JWMS 2016; 2, 60
  • Ecken S, Angermund S, Rassaf T, Hendgen-Cotta UB. AKT-mediated BNIP3 phosphorylation activates BCL-2 family member BAX. Eur Heart J. 2016;37 Suppl 1, 523
  • Pohl J, Papathanasiou M, Heisler M, Stock P, Kelm M, Hendgen-Cotta UB, Rassaf T, Luedike P. Renal replacement therapy neutralizes elevated MIF levels in septic shock. J Intensive Care 2016; 4:39
  • Ecken S, Hendgen-Cotta UB, Kelm M, Rassaf T. BNIP3 drives mitochondrial damage in the early phase of myocardial ischemia/reperfusion. Eur Heart J. 2015; 36, 169
  • Hendgen-Cotta UB, Luedike P, Totzeck M, Kropp M, Schicho A, Stock P, Rammos C, Niessen M, Heiss C, Lundberg JO, Weitzberg E, Kelm M, Rassaf T.Dietary nitrate supplementation improves revascularization in chronic ischemia. Circulation 2012; 126(16):1983-92
Collaborations
Back To Top