|Office:||MFZ 3. OG Room 03.026|
|Telefon:||+49 201 723 6054|
|Fax:||+49 201 723 6973|
Sebastian Korste graduated from University of Bielefeld in 2015 with a Master of Science in Molecular Cell Biology. He accomplished his master thesis at the Center of Biotechnology (CeBiTec) at the University of Bielefeld in the lab of Prof. Dr. Niehaus. He joined the University Hospital Essen in November 2015 as a research member of the CardioScienceLabs at the Depart-ment of Cardiology, simultaneously pursuing his PhD under the mentorship of Prof. Rassaf.
Myocardial Infarction is the leading cause of death worldwide. Cardiac tissue damage is mainly subjected to duration of ischemia and the detrimental effects of reperfusion. During ischemia, cardiac cells are deprived of much needed oxygen and energy supplies. Upon entry of reperfusion a rapid normalization in pH, a rise in calcium concentration and production of reactive oxygen species (ROS) induce even more cell stress. Various extrinsic and intrinsic signaling pathways, most of which still remain poorly understood, determine cell survival or cell death during this phenomen called ischemia-reperfusion(IR)-injury.
My work focuses on the role of integrin-associated proteins and calcium-dependent cysteine proteases in in vivo, ex vivo and in vitro models of IR-injury. The overlaying goal is to find novel therapeutic targets for myocardial IR-injury.