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Das Westdeutsche Herz- und Gefäßzentrum Essen mit der Klinik für Kardiologie und Angiologie befindet sich auf dem Gelände des Universitätsklinikums Essen. Sollten Sie die Routenplanung selbst vornehmen wollen, dann schauen Sie unsere Wegbeschreibung oder benutzen Sie bitte folgende Postadresse:

Hufelandstr. 55 | 45122 Essen

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Fax: +49 (201) 723 - 5480
Lageplan des Klinikums

Standort

We seek to understand the biological mechanisms behind acute cardiac damage in both basic and clinical science.

Our group led by PD Dr. Matthias Totzeck investigates pathological pathways associated with cardiac damage, which originates from e.g. acute myocardial infarction, valvular heart disease or in the course of cancer therapy. We aim to develop novel therapies for patient treatment.

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We use state-of-the-art technology and ground-breaking methodology in our day-to-day practice to drive innovative research for treatments of acute cardiac damage.
Clinical projects
Cardio-oncology
Characterization of the cardiovascular risks of antitumor therapies

Using meta-analytical techniques we evaluate the reported cardiovascular risks for specific tumor therapies. This includes antibody strategies, chemotherapeuticals and small molecules.

Evaluation of cardiovascular therapies in tumor patients

The optimal medical and interventional treatment of patients after tumor therapy or during ongoing or progressive disease is unknown. We evaluate strategies for such patients relating to coronary heart disease, coronary interventions and aortic valve disease. This includes novel imaging strategies (PET-MRI, global longitunial strain echocardiography). Read more … our ambulance

Univ.- Prof. Dr. med. Matthias Totzeck
Univ.- Prof. Dr. med. Matthias Totzeck
Basic science projects
Myocardial I/R Injury and repair

We seek to characterize potential mechanisms that can be used to reduce the burden of myocardial I/R which results from myocardial infarction and reperfusion therapy. We aim to optimize the immune response and the removal of dead cells after myocardial infarction which leads to the formation of an adequate remodelling and healling.

Stroke induced myocardial injury

The mechanism leading to stroke-induced myocardial injury are not known. We aim to characterize the immune response after stroke and whether it can be modified to obtain a reduction in cardiac damage.

Cancer therapy-related cardiotoxicity

Today, physicians face a growing number of long-term cancer survivors with morbidities resulting from therapy. The underlying mechanisms are still unknown. We mimic cancer treatments used in clinical practice to investigate pathologies of the heart in basic science and develop therapeutic strategies to counteract cardiovascular damage.

Basic science methods
Models
  • Mouse in vivo myocardial I/R injury
  • Isolated mouse hearts (Langendorff)
  • Isolated aortic rings
  • Human cardiomyocytes
  • Isolated primary mouse cardiomyocytes
In vivo functional analysis
  • Millar catheter
  • Mouse echocardiography
Protein and RNA analytical methods
Microscopy
  • FACS/flow cytometry
  • Confocal microscopy
  • Light sheet fluorescence microscopy
Funding
  • ESC Research Grant 2016 to Dr. Raluca Ileana Mincu
  • Internal research funding for clinicians (IFORES) 2018-2019 to Dr. Lars Michel
  • Internal research funding for clinicians (IFORES) 2018-2019 to Dr. Simone Mrotzek
  • DZHK grant 2019-2020 to PD Dr. Matthias Totzeck in conjunction with Prof. Dr. Matthias
    Gunzer (UDE) and Prof. Dr. Thomas Braun (MPI Bad Nauheim)
  • Josepha and Charlotte von Siebold habilitation funding 2019-2020 to Dr. Raluca Ileana Mincu
Kooperationen
  • External
    • Stanford Institute for Stem Cell Biology and Regnerative Medicine
    • Pittsburgh Heart, Lung, Blood and Vascular Medicine Institute
    • MPI for Heart and Lung Research Bad Nauheim
    • ISAS Dortmund
    • Berlin-Brandenburg Center for Regenerative Therapies
  • On campus
    • Institute for Experimental Immunology and Imaging
    • Institute of Cell Biology (Cancer Research)
    • Institute for Pathophysiology
    • Department of Nuclear Medicine
    • Institute for Diagnostic and Interventional Radiology
    • Department of Dermatology
    • Department of Thoracic and Cardiovascular Surgery

Publications

  • 2019
    • Mincu…Totzeck JAMA Netw Open
      Cardiovascular Adverse Events Associated With BRAF and MEK Inhibitors:
      A Systematic Review and Meta-analysis.
    • Al-Rashid, Totzeck et al. Int J Cardiol
      Safety and efficacy of a novel algorithm to guide decision-making in high-risk
      interventional coronary procedures.
    • Totzeck, Mincu et al. ESC Heart Fail
      Heart failure from cancer therapy: can we prevent it?
    • Merz, Korste…Totzeck Nat Commun
      Contemporaneous 3D characterization of acute and chronic myocardial I/R injury and response.
    • Mincu…Totzeck, Rassaf Sci Rep
      Novel anticoagulants versus vitamin K antagonists for cardioversion of non- valvular
      atrial fibrillation – a meta-analysis of more than 17000 patients.
    • Hinrichs…Totzeck Am J Case Rep
      Diagnostic Work-Up of Pulmonary Hypertension – Think About Shunt Flow!
      A Case Report
    • Totzeck et al. Int J Cardiol
      Cardio-oncology – strategies for management of cancer-therapy related cardiovascular disease
    • Totzeck et al. Eur Heart J
      Weightlifting unmasks high-risk coronary anomaly

    2018

    • Hinrichs…Totzeck Eur Heart J Case Rep
      Malaise and fatigue following mitral valve repair: case report
    • Rassaf, Totzeck J Thorac Dis
      Modern concepts in cardio-oncology
    • Michel…Totzeck J Thorac Dis
      iomarkers for the detection of apparent and subclinical cancer therapy-related cardiotoxicity
    • Mincu…Totzeck Neth Heart J
      Red blood cell transfusion in patients with ST-elevation myocardial infarction-
      a meta-analysis of more than 21,000 patients
    • Michel…Totzeck…Hendgen-Cotta J Vis Exp
      Real-time Pressure-volume Analysis of Acute Myocardial Infarction in Mice
    • Rischpler, Totzeck J Nucl Cardiol
      Are you stressed?
    • Totzeck, Mincu, Mrotzek et al. Eur J Prev Cardiol
      Cardiovascular diseases in patients receiving small molecules with anti-vascular endothelial
      growth factor activity: A meta-analysis of approximately 29,000 cancer patients

    2017

    • Mrotzek, Totzeck Am J Case Rep
      Ticagrelor Leads to Statin-Induced Rhabdomyolysis: A Case Report
    • Totzeck, Mincu et al. J Am Heart Assoc
      Cardiovascular Adverse Events in Patients With Cancer Treated With Bevacizumab:
      A Meta-Analysis of More Than 20 000 Patients
    • Totzeck et al. Adv Exp Med Biol
      Nitrite-Nitric Oxide Signaling and Cardioprotection
    • Totzeck, Korste et al. Nitric Oxide
      S-nitrosation of calpains is associated with cardioprotection in myocardial I/R injury
    • Hendgen-Cotta…Totzeck Sci Rep
      A novel physiological role for cardiac myoglobin in lipid metabolism
    • Mincu…Totzeck Sci Rep
      Preprocedural C-Reactive Protein Predicts Outcomes after Primary Percutaneous Coronary
      Intervention in Patients with ST-elevation Myocardial Infarction a systematic meta-analysis
    • Hendgen-Cotta, Messiha…Totzeck Free Radic Res
      Inorganic nitrite modulates miRNA signatures in acute myocardial in vivo ischemia/reperfusion

    2016

    • Totzeck et al. J Biol Methods
      A practical approach to remote ischemic preconditioning and ischemic preconditioning
      against myocardial ischemia/reperfusion injury

    2015

    • Totzeck et al. World J Cardiol
      Concepts of hypoxic NO signaling in remote ischemic preconditioning
    • Totzeck et al. Mol Cell Biochem
      Nitrite circumvents canonical cGMP signaling to enhance proliferation of myocyte precursor cells

    2014

    • Totzeck et al. PLoS One
      Crosstalk between nitrite, myoglobin and reactive oxygen species to regulate
      vasodilation under hypoxia
    • Rassaf, Totzeck et al. Circ Res
      Circulating nitrite contributes to cardioprotection by remote ischemic preconditioning

    2012

    • Totzeck et al. Circulation
      Nitrite regulates hypoxic vasodilation via myoglobin-dependent nitric oxide generation
    • Totzeck et al. Nitric Oxide
      Higher endogenous nitrite levels are associated with superior exercise capacity
      in highly trained athletes
    • Totzeck et al. Nitric Oxide
      Assessment of the functional diversity of human myoglobin

Awards

2019

  • ESC Educational Grant
    Dr. Lars Michel, Dr. Simone Mrotzek and Dr. Raluca Ileana Mincu
  • ESC Basic Science Travel Grant
    Sebastian Korste
  • Best Poster Award at the 85th congress of the German Society of Cardiology
    Dr. Lars Michel

2018

  • ESC Basic Science Travel Grant
    Dr. Lars Michel

2016

  • ESC Basic Science Travel Grant
    Sebastian Korste

Unser Team

Interested to work with us? Please contact: PD Dr. Matthias Totzeck

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